Calorie Restriction Longevity Humans
Physiology of fasting and calorie restriction in humans.?
Human trials/personal experience? Physiological effects on the body, specifically to brain function and subjective perception?
Not trying to lose weight- calories would be compensated for on previous days.
Several studies have shown that cal. restricted diets increase lifespan. Mice that fasted every three days showed the same results.
I’m looking for the impact short, medium and long term. Chemically what goes on in the body while fasting that would contribute to an increase in lifespan.
If anyone knows of human trails or voluntary experiments, please point me toward the article/journal. I am considering a diet that includes fasting and/or calorie restriction. Longevity is not the focus- primary goal is improving subjective experiences (depth, complexity, intensity, speed, etc.)
Here are some of the recent publication on the subject, i hope these and the references given therein will be helpful for you. You can look for more on pubmed and google scholar.
1: Redman LM, Ravussin E.
Endocrine alterations in response to calorie restriction in humans.
Mol Cell Endocrinol. 2008 Oct 21. [Epub ahead of print]
PMID: 19007855 [PubMed - as supplied by publisher]
2: Fontana L, Weiss EP, Villareal DT, Klein S, Holloszy JO.
Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3
concentration in humans.
Aging Cell. 2008 Oct;7(5):681-7.
PMID: 18843793 [PubMed - indexed for MEDLINE]
3: Allard JS, Heilbronn LK, Smith C, Hunt ND, Ingram DK, Ravussin E; Pennington
CALERIE Team, de Cabo R.
In vitro cellular adaptations of indicators of longevity in response to treatment
with serum collected from humans on calorie restricted diets.
PLoS ONE. 2008 Sep 15;3(9):e3211.
PMID: 18791640 [PubMed - indexed for MEDLINE]
4: Marzetti E, Lawler JM, Hiona A, Manini T, Seo AY, Leeuwenburgh C.
Modulation of age-induced apoptotic signaling and cellular remodeling by exercise
and calorie restriction in skeletal muscle.
Free Radic Biol Med. 2008 Jan 15;44(2):160-8. Epub 2007 May 31. Review.
PMID: 18191752 [PubMed - indexed for MEDLINE]
5: Carter CS, Hofer T, Seo AY, Leeuwenburgh C.
Molecular mechanisms of life- and health-span extension: role of calorie
restriction and exercise intervention.
Appl Physiol Nutr Metab. 2007 Oct;32(5):954-66. Review.
PMID: 18059622 [PubMed - indexed for MEDLINE]
6: Everitt AV, Le Couteur DG.
Life extension by calorie restriction in humans.
Ann N Y Acad Sci. 2007 Oct;1114:428-33. Epub 2007 Aug 23. Review.
PMID: 17717102 [PubMed - indexed for MEDLINE]
7: Holloszy JO, Fontana L.
Caloric restriction in humans.
Exp Gerontol. 2007 Aug;42(8):709-12. Epub 2007 Mar 31. Review.
PMID: 17482403 [PubMed - indexed for MEDLINE]
Response to Comments on My Anti-Fruitarian Videos ~ Calorie Restriction (Part 1 of 3) #125